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EAAT2 rabbit pAb
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ES20771
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50 µL $148.00
100 µL $248.00
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Overview

Product name: EAAT2 rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthetic Peptide of EAAT2 AA range: 370-420
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 62kD
GeneID: 6506
Human Swiss-Prot No: P43004
Cellular localization: Cell membrane ; Multi-pass membrane protein .
Background: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],