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Endothelin B Receptor rabbit pAb
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ES20766
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Endothelin B Receptor rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: Endothelin B receptor (ET-B;ET-BR;Endothelin receptor non-selective type)
Source: Rabbit
Dilutions: IHC 1:100-200
Immunogen: Synthetic Peptide of Endothelin B Receptor AA range: 270-350
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 50kD
GeneID: 1910
Human Swiss-Prot No: P24530
Cellular localization: Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. .
Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],