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ERK 5 rabbit pAb
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ES20759
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50 µL $148.00
100 µL $248.00
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Overview

Product name: ERK 5 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5
Source: Rabbit
Dilutions: WB: 1:1000-2000 IHC:1:200-500
Immunogen: Recombinant Protein of ERK 5
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 89-115kD
GeneID: 5598
Human Swiss-Prot No: Q13164
Cellular localization: Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],