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GABA A Receptor α4 rabbit pAb
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ES20748
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50 µL $148.00
100 µL $248.00
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Overview

Product name: GABA A Receptor α4 rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4
Source: Rabbit
Dilutions: WB 1:1000-2000, IHC 1:100-200
Immunogen: Synthetic Peptide of GABA A Receptor α4 AA range: 149-199
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 62kD
GeneID: 2557
Human Swiss-Prot No: P48169
Cellular localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Background: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],