Products

GABA B Receptor 2 rabbit pAb
One-click to copy product information
ES20746
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: GABA B Receptor 2 rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20
Source: Rabbit
Dilutions: IHC 1:100-200
Immunogen: Synthetic Peptide of GABA B Receptor 2 AA range: 785-835
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 106kD
GeneID: 9568
Human Swiss-Prot No: O75899
Cellular localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. .
Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010],