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MEK-5 rabbit pAb
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ES20665
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MEK-5 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5
Source: Rabbit
Dilutions: WB: 1:1000-2000 IHC: 1:200-500
Immunogen: Recombinant Protein of MEK-5
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 49kD
GeneID: 5067
Human Swiss-Prot No: Q13163
Cellular localization: nucleus,cytoplasm,spindle,cytosol,
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011],