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NM23A Rabbit rabbit pAb
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ES20658
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50 µL $148.00
100 µL $248.00
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Overview

Product name: NM23A Rabbit rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: NME1
Source: Rabbit
Dilutions: IHC 1:100-200
Immunogen: Recombinant Protein of NM23A of NME1
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 17kD
GeneID: 4830
Human Swiss-Prot No: P15531
Cellular localization: Cytoplasm . Nucleus . Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Background: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008],