Products

PEPC rabbit pAb
One-click to copy product information
ES20649
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: PEPC rabbit pAb
Reactivity: Plants
Alternative Names: PGC; Gastricsin; Pepsinogen C
Source: Rabbit
Dilutions: WB: 1:2000-5000
Immunogen: Synthetic Peptide of PEPC
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 105-109kD
Cellular localization: extracellular space,extracellular exosome,
Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],