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SOD1 rabbit pAb
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ES20629
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50 µL $148.00
100 µL $248.00
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Overview

Product name: SOD1 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from the Internal region of human SOD-1.
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed Band: 18kD
GeneID: 6647
Human Swiss-Prot No: P00441
Cellular localization: Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. .
Background: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008],