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TBP rabbit pAb
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ES20613
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50 µL $148.00
100 µL $248.00
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Overview

Product name: TBP rabbit pAb
Reactivity: Human;Rat;Mouse
Alternative Names: TATA-box-binding protein (TATA sequence-binding protein;TATA-binding factor;TATA-box factor;Transcription initiation factor TFIID TBP subunit)
Source: Rabbit
Dilutions: WB: 1:500-1:2000 IHC: 1:50-1:200
Immunogen: Recombinant Protein of TBP
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 38kD
GeneID: 6908
Human Swiss-Prot No: P20226
Cellular localization: Nucleus .
Background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA bin