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TLR2 rabbit pAb
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ES20606
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50 µL $148.00
100 µL $248.00
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Overview

Product name: TLR2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: TLR2; TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282
Source: Rabbit
Dilutions: IHC: 1:200-500
Immunogen: Recombinant Protein of TLR2
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
GeneID: 7097
Human Swiss-Prot No: O60603
Cellular localization: Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. .
Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],