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Crk-L rabbit pAb
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ES2053
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Crk-L rabbit pAb
Reactivity: Human;Mouse;Rat;Monkey
Alternative Names: CRKL; Crk-like protein
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CrkL. AA range:173-222
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 39kD
GeneID: 1399
Human Swiss-Prot No: P46109
Cellular localization: endosome,cytosol,cell-cell adherens junction,extracellular exosome,
Background: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],