Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:
Purified recombinant fragment of human IRE1α (aa282-433) expressed in E. Coli.
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Molecular Weight:
105kD
GeneID:
2081
Human Swiss-Prot No:
O75460
Cellular localization:
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Background:
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008],
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