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PDCD1 rabbit pAb
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ES20415
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PDCD1 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Programmed cell death protein 1 (Protein PD-1;hPD-1;CD antigen CD279)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: Synthesized peptide derived from human PDCD1
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 32kD
GeneID: 5133
Human Swiss-Prot No: Q15116
Cellular localization: Cell membrane ; Single-pass type I membrane protein.
Background: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],