Product name: |
DR5 rabbit pAb |
Reactivity: |
Human;Rat;Mouse; |
Alternative Names: |
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5;TNF-related apoptosis-inducing ligand receptor 2;TRAIL receptor 2;TRAIL-R2;CD antigen CD262) |
Source: |
Rabbit |
Dilutions: |
WB 1:1000-2000 ELISA 1:5000-20000 |
Immunogen: |
Synthesized peptide derived from human DR5 AA range: 200-280 |
Storage: |
-20°C/1 year |
Clonality: |
Polyclonal |
Isotype: |
IgG |
Concentration: |
1 mg/ml |
Molecular Weight: |
48kD |
GeneID: |
8795 |
Human Swiss-Prot No: |
O14763 |
Cellular localization: |
Membrane; Single-pass type I membrane protein. |
Background: |
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009], |