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Smad2/3 (Acetyl Lys420/378) rabbit pAb
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ES20124
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Smad2/3 (Acetyl Lys420/378) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Mothers against decapentaplegic homolog 2 (MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human Smad2/3 (Acetyl Lys420/378)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 55kD
GeneID: 4087
Human Swiss-Prot No: Q15796/P84022
Cellular localization: Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .