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Histone H2A.Z (Acetyl Lys12) rabbit pAb
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ES20073
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Histone H2A.Z (Acetyl Lys12) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Histone H2A.Z (H2A/z)
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys12)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 15kD
GeneID: 3015
Human Swiss-Prot No: P0C0S5
Cellular localization: Nucleus. Chromosome.
Background: function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.,mass spectrometry:Monoisotopic, not modified PubMed:16457589,PTM:Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.,PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.,PTM:Not phosphorylated.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.,