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Plasma Kallikrein LC (Cleaved-I391) rabbit pAb
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ES20042
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Plasma Kallikrein LC (Cleaved-I391) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Plasma kallikrein (EC 3.4.21.34;Fletcher factor;Kininogenin;Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 28 70kD
GeneID: 3818
Human Swiss-Prot No: P03952
Cellular localization: Secreted.
Background: catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.,disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect.,function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,