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MMP8 (Cleaved-Leu101) rabbit pAb
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ES20030
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MMP8 (Cleaved-Leu101) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human MMP8 (Cleaved-Leu101)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 40 53kD
GeneID: 4317
Human Swiss-Prot No: P22894
Cellular localization: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.
Background: catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,