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ITGAE (light chain, Cleaved-Arg177) rabbit pAb
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ES20010
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50 µL $148.00
100 µL $248.00
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Overview

Product name: ITGAE (light chain, Cleaved-Arg177) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Integrin alpha-E (HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human ITGAE (light chain, Cleaved-Arg177)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 17 128kD
GeneID: 3682
Human Swiss-Prot No: P38570
Cellular localization: Membrane; Single-pass type I membrane protein.
Background: integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],