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CFAD (Cleaved-Ile26) rabbit pAb
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ES19983
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CFAD (Cleaved-Ile26) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Complement factor D (EC 3.4.21.46;Adipsin;C3 convertase activator;Properdin factor D)
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human CFAD (Cleaved-Ile26)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 25kD
GeneID: 1675
Human Swiss-Prot No: P00746
Cellular localization: Secreted.
Background: catalytic activity:Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.,disease:Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,function:Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.,online information:CFD mutation db,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,