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Collagen XVIII α1 (Cleaved-His1572) rabbit pAb
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ES19979
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Overview

Product name: Collagen XVIII α1 (Cleaved-His1572) rabbit pAb
Reactivity: Human;Mouse
Alternative Names: Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 20 200kD
GeneID: 80781
Human Swiss-Prot No: P39060
Cellular localization: Secreted, extracellular space, extracellular matrix . Secreted, extracellular space, extracellular matrix, basement membrane .; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane . Secreted .; [Endostatin]: Secreted . Secreted, extracellular space, extracellular matrix, basement membrane .
Background: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],