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Collagen V α1 (Cleaved-Ala1605) rabbit pAb
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ES19976
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Collagen V α1 (Cleaved-Ala1605) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Collagen alpha-1(V) chain
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Collagen V α1 (Cleaved-Ala1605)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 175 202kD
GeneID: 1289
Human Swiss-Prot No: P20908
Cellular localization: Secreted, extracellular space, extracellular matrix .
Background: disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.,disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome.,function:Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:Sulfated on 40% of tyrosines.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.,