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Collagen I α1 (Cleaved-Ala1218) rabbit pAb
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ES19972
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Collagen I α1 (Cleaved-Ala1218) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Collagen alpha-1(I) chain (Alpha-1 type I collagen)
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human Collagen I α1 (Cleaved-Ala1218)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 135 160kD
GeneID: 1277
Human Swiss-Prot No: P02452
Cellular localization: Secreted, extracellular space, extracellular matrix .
Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],