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FA11 (heavy chain, Cleaved-Arg387) rabbit pAb
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ES19969
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50 µL $148.00
100 µL $248.00
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Overview

Product name: FA11 (heavy chain, Cleaved-Arg387) rabbit pAb
Reactivity: Human; Mouse
Alternative Names: Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Arg387)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 40 66kD
GeneID: 2160
Human Swiss-Prot No: P03951
Cellular localization: Secreted.
Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008],