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CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb
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ES19961
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Cathepsin L1 (EC 3.4.22.15;Major excreted protein;MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 25 37kD
GeneID: 1514
Human Swiss-Prot No: P07711
Cellular localization: Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .
Background: catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,