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CATB (Cleaved-Leu80) rabbit pAb
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ES19957
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CATB (Cleaved-Leu80) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Cathepsin B (EC 3.4.22.1;APP secretase;APPS;Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Source: Rabbit
Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human CATB (Cleaved-Leu80)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 28 37kD
GeneID: 1508
Human Swiss-Prot No: P07858
Cellular localization: Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
Background: catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,