| Product name: |
Choactase rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
82,70kD |
| GeneID: |
1103 |
| Human Swiss-Prot No: |
P28329 |
| Cellular localization: |
nucleus,cytoplasm,cytosol,presynapse, |
| Background: |
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010], |
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