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1C04 rabbit pAb
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ES18543
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50 µL $148.00
100 µL $248.00
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Overview

Product name: 1C04 rabbit pAb
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human 1C04 AA range: 110-160
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 40kD
Human Swiss-Prot No: P30504
Cellular localization: ane,extracellular region,endoplasmic reticulum,atus,plasma membrane,integral component of plasma membrane,cell surface,ER to port vesicle membrane,membrane,integral component of membrane,phaicle membrane,early endosome membrane,MHC class I protein complex,MHC class II protein complex,extracellular exosome,integral component of lumenal side of endoplasmic reticulum membrane,
Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008],