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53BP1 (phospho-Ser1778) rabbit pAb
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ES18530
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50 µL $148.00
100 µL $248.00
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Overview

Product name: 53BP1 (phospho-Ser1778) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human 53BP1 (Ser1778)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 213kD
GeneID: 7158
Human Swiss-Prot No: Q12888
Cellular localization: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .