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Alix rabbit pAb
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ES18395
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Alix rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Programmed cell death 6-interacting protein (PDCD6-interacting protein;ALG-2-interacting protein 1;Hp95)
Source: Rabbit
Dilutions: WB 1:500-2000, ELISA(peptide)1:5000-20000
Immunogen: Synthesized peptide derived from human Alix AA range: 410-490
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 85-100kD
GeneID: 10015
Human Swiss-Prot No: Q8WUM4
Cellular localization: Cytoplasm, cytosol . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Secreted, extracellular exosome . Cell junction, tight junction . Midbody, Midbody ring . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129). .
Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012],