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ARVC rabbit pAb
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ES18243
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50 µL $148.00
100 µL $248.00
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Overview

Product name: ARVC rabbit pAb
Reactivity: Human; Mouse
Alternative Names: Armadillo repeat protein deleted in velo-cardio-facial syndrome
Source: Rabbit
Dilutions: WB 1:500-2000
Immunogen: Synthesized peptide derived from human ARVC AA range: 563-613
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 105kD
GeneID: 421
Human Swiss-Prot No: O00192
Cellular localization: Cell junction .
Background: Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010],