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CARD11 (phospho-Ser652) rabbit pAb
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ES17855
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CARD11 (phospho-Ser652) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human CARD11 (Ser652)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 84433
Human Swiss-Prot No: Q9BXL7
Cellular localization: Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],