Products

DEN1A rabbit pAb
One-click to copy product information
ES16971
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: DEN1A rabbit pAb
Reactivity: Human; Mouse
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human DEN1A AA range: 14-64
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 111kD
GeneID: 57706
Human Swiss-Prot No: Q8TEH3
Cellular localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .
Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],