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DEN1B rabbit pAb
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ES16970
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DEN1B rabbit pAb
Reactivity: Human; Mouse
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human DEN1B AA range: 325-375
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 47kD
GeneID: 163486
Human Swiss-Prot No: Q6P3S1
Cellular localization: Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle .
Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],