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Desmoplakin (phospho-Ser165/166) rabbit pAb
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ES16959
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Overview

Product name: Desmoplakin (phospho-Ser165/166) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human Desmoplakin (Ser165 and 166)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 300kD
GeneID: 1832
Human Swiss-Prot No: P15924
Cellular localization: Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity). .
Background: This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],