DESP rabbit pAb

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DESP rabbit pAb

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ES16958

Size：	Price：
50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	DESP rabbit pAb
Reactivity:	Human; Mouse
Source:	Rabbit
Dilutions:	IHC-p 1：50-200
Immunogen:	Synthesized peptide derived from human DESP AA range: 1546-1596
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Molecular Weight:	316kD
GeneID:	1832
Human Swiss-Prot No:	P15924
Cellular localization:	Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity). .
Background:	This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).