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DFFB rabbit pAb
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ES16956
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DFFB rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: DNA fragmentation factor subunit beta (EC 3.-.-.-;Caspase-activated deoxyribonuclease;CAD;Caspase-activated DNase;Caspase-activated nuclease;CPAN;DNA fragmentation factor 40 kDa subunit;DFF-40)
Source: Rabbit
Dilutions: IHC-p 1:50-200, WB 1:500-2000
Immunogen: Synthesized peptide derived from human DFFB
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 37kD
GeneID: 1677
Human Swiss-Prot No: O76075
Cellular localization: Cytoplasm. Nucleus.
Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013],