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DOCK4 rabbit pAb
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ES16916
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DOCK4 rabbit pAb
Reactivity: Human; Mouse
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human DOCK4 AA range: 533-583
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 216kD
GeneID: 9732
Human Swiss-Prot No: Q8N1I0
Cellular localization: Cell membrane . Cell projection . Cytoplasm, cytosol . Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. .
Background: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008],