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DR6 (phospho-Ser562) rabbit pAb
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ES16898
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DR6 (phospho-Ser562) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human DR6 (Ser562)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 72kD
GeneID: 27242
Human Swiss-Prot No: O75509
Cellular localization: Cell membrane ; Single-pass type I membrane protein .
Background: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],