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DU4L7 rabbit pAb
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ES16882
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DU4L7 rabbit pAb
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human DU4L7 AA range: 314-364
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 47kD
Human Swiss-Prot No: P0CJ90
Cellular localization: Nucleus .
Background: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014],