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DUOX1 rabbit pAb
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ES16881
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DUOX1 rabbit pAb
Reactivity: Human;Rat
Source: Rabbit
Dilutions: WB 1：500-2000
Immunogen: Synthesized peptide derived from human DUOX1 AA range: 1398-1448
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 171kD
GeneID: 53905
Human Swiss-Prot No: Q9NRD9
Cellular localization: Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.
Background: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],