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DYL1 rabbit pAb
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ES16868
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50 µL $148.00
100 µL $248.00
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Overview

Product name: DYL1 rabbit pAb
Reactivity: Human; Mouse;Rat
Source: Rabbit
Dilutions: IHC-p 1：50-200
Immunogen: Synthesized peptide derived from human DYL1 AA range: 1-50
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 10kD
GeneID: 8655
Human Swiss-Prot No: P63167
Cellular localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Nucleus . Mitochondrion . Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. .
Background: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],