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APC5 rabbit pAb
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ES1676
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50 µL $148.00
100 µL $248.00
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Overview

Product name: APC5 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 85kD
GeneID: 51433
Human Swiss-Prot No: Q9UJX4
Cellular localization: Nucleus . Cytoplasm, cytoskeleton, spindle .
Background: This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],