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FBX32 rabbit pAb
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ES16504
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50 µL $148.00
100 µL $248.00
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Overview

Product name: FBX32 rabbit pAb
Reactivity: Human; Mouse;Rat
Alternative Names: F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
Source: Rabbit
Dilutions: WB 1:500-2000
Immunogen: Synthesized peptide derived from human FBX32 AA range: 217-267
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 38kD
GeneID: 114907
Human Swiss-Prot No: Q969P5
Cellular localization: Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],