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MLK3 (phospho Ser674) rabbit pAb
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ES1535
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MLK3 (phospho Ser674) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human MLK3 (phospho Ser674)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 93kD
GeneID: 4296
Human Swiss-Prot No: Q16584
Cellular localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.
Background: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],