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MCLN2 rabbit pAb
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ES15002
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MCLN2 rabbit pAb
Reactivity: Human; Mouse
Alternative Names: Mucolipin-2
Source: Rabbit
Dilutions: WB 1:500-2000
Immunogen: Synthesized peptide derived from human MCLN2 AA range: 328-378
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 60kD
GeneID: 255231
Human Swiss-Prot No: Q8IZK6
Cellular localization: Cell membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Localizes to recycling endosomes in activated macrophages and microglia. .
Background: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009],