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MLKL (phospho Ser358) rabbit pAb
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ES14935
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MLKL (phospho Ser358) rabbit pAb
Reactivity: Human
Alternative Names: Mixed lineage kinase domain-like protein
Source: Rabbit
Dilutions: IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000
Immunogen: Synthesized peptide derived from human MLKL (phospho S358)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 55kD
GeneID: 197259
Human Swiss-Prot No: Q8NB16
Cellular localization: Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],