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Myosin IIa (phospho-Ser1943) rabbit pAb
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ES14587
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Myosin IIa (phospho-Ser1943) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized phosho peptide around human Myosin IIa (Ser1943)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 215kD
GeneID: 4627
Human Swiss-Prot No: P35579
Cellular localization: Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle, secretory vesicle, Cortical granule . Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). .
Background: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011],