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NuMA (phospho-Ser395) rabbit pAb
ES14427
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50 µL $148.00
100 µL $248.00
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Overview

Product name: NuMA (phospho-Ser395) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen)
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human NuMA (Ser395)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 240kD
GeneID: 4926
Human Swiss-Prot No: Q14980
Cellular localization: Nucleus . Nucleus, nucleoplasm . Nucleus matrix . Chromosome . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cell cortex . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Lateral cell membrane . Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:1541636, PubMed:10811826). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). In interphase, resides in the nuclear matrix (PubMed:1541630, PubMed:1541636, PubMed:23921553). In prophase, restricted to the interchromatin or condensed chromosome space (PubMed:10811826). In prometaphase, after nuclear envelope disassembly, forms aggregates
Background: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],